Arrange the given organs in correct sequence which are involved in life cycle of Plasmodium.

(A) Gut of mosquito
(B) Salivary gland of mosquito
(C) Liver of man
(D) Blood of man

Choose the correct answer from the options given below.

(B), (C), (D), (A)

The correct answer is Option (4) → (B), (C), (D), (A)

• (B) Salivary gland of mosquito: The cycle begins when an infected female Anopheles mosquito bites a human, injecting sporozoites that were stored in its salivary glands.

• (C) Liver of man: These sporozoites travel through the bloodstream and reach the liver. They infect liver cells, where they multiply asexually (pre-erythrocytic stage).

• (D) Blood of man: The parasites burst out of the liver cells and enter the Red Blood Cells (RBCs). This is the stage where they multiply further and cause the clinical symptoms of malaria. Some eventually develop into sexual stages (gametocytes).

• (A) Gut of mosquito: When a new mosquito bites the infected person, it sucks up the gametocytes. The fertilization and development of the parasite take place in the mosquito's intestine (gut).

This sequence matches Option 4

• Human Stages: Salivary Gland (transfer) $\to$ Liver $\to$ Blood.

• Mosquito Stages: Blood (transfer) $\to$ Gut.

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•                                   Stages in the life cycle of Plasmodium