The most appropriate antonym of the word "perturb" is soothe.
- Perturb means "to disturb the peace or calm of (someone or something); to make (someone) feel anxious or unsettled."
- Soothe means "to make (someone or something) feel calmer or more relaxed."
The other words do not have the opposite meaning of "perturb."
- Confound means "to confuse or puzzle (someone)."
- Commend means "to praise or express approval of (someone or something)."
- Fluster means "to make (someone) feel confused, anxious, or disconcerted."
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