Which one is responsible to cause inbreeding depression?

Continued self-pollination.

The correct answer is Option (1) – Continued self-pollination.

Inbreeding depression is a decrease in the fitness of a population due to the mating of closely related individuals.

Continued self-pollination is the most common cause of inbreeding depression. This is because self-pollination increases the chances that two copies of the same harmful allele will be inherited by the offspring. This can lead to a number of problems, including decreased fertility, increased mortality, and decreased fitness.

No pollination and continued cross pollination do not cause inbreeding depression. No pollination will simply prevent the population from reproducing, while continued cross pollination will increase the genetic diversity of the population, which can help to reduce the effects of inbreeding depression.

Therefore, the answer is continued self-pollination.