Target Exam

CUET

Subject

Biology

Chapter

Biotechnology and its Applications

Question:

The first clinical gene therapy was given in 1990 to a 4-year old girl with____________.

Options:

Adenosine aminase deficiency

Cytosine deaminase deficiency

Adenosine deaminase deficiency

Adenosine protease deficiency

Correct Answer:

Adenosine deaminase deficiency

Explanation:

The correct answer is Option (3) → Adenosine deaminase deficiency

Gene therapy is a collection of methods that allows correction of a gene defect that has been diagnosed in a child/embryo. Here genes are inserted into a person’s cells and tissues to treat a disease. Correction of a genetic defect involves delivery of a normal gene into the individual or embryo to take over the function of and compensate for the non-functional gene. The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency.This enzyme is crucial for the immune system to function. The disorder is caused due to the deletion of the gene for adenosine deaminase.