Fill in the blanks with the appropriate propositions from the given options:

He often goes _________ school ________ his mother.

to, with

The correct answer is OPTION 1 - to, with

The complete sentence would be: "He often goes to school with his mother."

"Goes to school" is the correct phrase indicating the action of attending school.

- "With his mother" indicates the manner or accompaniment of going to school.