Select the most appropriate word to fill in the blank.

Do not meddle ______ the affairs of others.

in

The most appropriate word to fill in the blank is in.

The word "meddle" means to interfere in the affairs of others in a way that is not welcome or appropriate. The preposition "in" is used to indicate location or involvement. In this sentence, the speaker is telling the listener not to interfere in the affairs of others.

The other options are not as appropriate.

• The preposition "to" is used to indicate direction or purpose. It does not make sense to say that the listener should not meddle to the affairs of others.
• The preposition "from" is used to indicate separation or distance. It does not make sense to say that the listener should not meddle from the affairs of others.
• The preposition "at" is used to indicate a point in time or space. It does not make sense to say that the listener should not meddle at the affairs of others.
• The preposition "on" is used to indicate a surface or support. It does not make sense to say that the listener should not meddle on the affairs of others.