The most appropriate synonym of the word "culpable" is guilty.
- Culpable means deserving blame or censure as being wrong or evil or injurious.
- Guilty means deserving blame or punishment for a wrong or offense.
- Irresponsible means not showing or having a sense of responsibility.
- Immune means not affected by or not susceptible to a particular disease or condition.
- Innocent means not guilty of a crime or offense.
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