Select the most appropriate word to fill in the blank.

I had a stroke at an early age, but what I thought was a great ______ at that time changed my life for the better.

setback

The most appropriate word to fill in the blank is setback.

• Lowliness means the state of being humble or modest.
• Significance means the importance or meaning of something.
• Setback means a temporary reverse or misfortune.
• Moodiness means the tendency to be easily upset or irritable.