Match the LIST-I with LIST-II
| LIST-I | LIST-II |
|---|---|
| Years of Invention | Types of Inventions |
| A. 1972 | I. First genetically engineered insulin |
| B. 1983 | II. First recombinant DNA |
| C. 1990 | III. First transgenic cow |
| D. 1997 | IV. First clinical gene therapy |
Choose the correct answer from the options given below:
Answer & explanation
Correct answer: option 2
The correct answer is Option (2) → A-II, B-I, C-IV, D-III
(A) 1972 — this matches (II) First recombinant DNA. Stanley Cohen and Herbert Boyer made it by linking an antibiotic resistance gene to a plasmid of Salmonella typhimurium.
(B) 1983 — this matches (I) First genetically engineered insulin. In that year Eli Lilly, an American company, prepared DNA sequences for the A and B chains of human insulin and put them into plasmids of E. coli.
(C) 1990 — this matches (IV) First clinical gene therapy. It was given to a 4-year-old girl who lacked the enzyme adenosine deaminase (ADA).
(D) 1997 — this matches (III) First transgenic cow. The cow, Rosie, gave milk enriched with the human protein alpha-lactalbumin.