Which of the following biomolecules does have a phosphodiester bond?

Nucleic acids in a nucleotide.

The correct answer is Option (2) -  Nucleic acids in a nucleotide.

• In each polynucleotide chain, the deoxyribose molecules of two adjacent nucleotides are linked through one phosphate molecule by a phosphodiester bond.
• Fatty acids in a diglyceride have an ester bond.
• Monosaccharides in polysaccharides have a glycosidic bond.
• Amino acids in a polypeptide have a peptide bond.