The most appropriate synonym of the word "despair" is desperation.
- Despair is a feeling of hopelessness and loss of all hope.
- Desperation is a state of mind characterized by extreme anxiety and a feeling that there is no way out of a difficult situation.
- Delighted is a feeling of great joy and happiness.
- Happy is a feeling of contentment and well-being.
- Determine is to set one's mind to do something and to persist in doing it despite difficulties.
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