Which of the following is true about phosphodiester linkage?

3’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide 5’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide 3’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide.