The most appropriate synonym of the given word indignation is offense.
- Indignation means "a feeling of anger or strong disapproval."
- Offense means "a feeling of anger or displeasure caused by something considered unjust, insulting, or harmful."
- Designation means "the act of giving a name or title to something."
- Resignation means "the act of giving up something, especially a job or position."
- Defense means "the action of defending someone or something against attack or criticism."
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