CUET Preparation Today
Case: Read the following passage and answer accordingly Amines are prepared mainly by the reduction of nitro compounds. Alkyl or benzyl halide on reaction with an ethanolic solution of ammonia undergoes nucleophilic substitution reaction in which the halogen atom is replaced by an amino group. Amines are prepared from Phthalimide. Treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide result in amines. |
| Which is the most convenient method to prepare primary amine-containing one carbon atom less? |
Gabriel phthalmidie synthesis Reductive amination of aldehydes Hofmann bromamide reaction All of these |
| Hofmann bromamide reaction |
| Hoffmann developed a method for the preparation of primary amines by treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide. In this degradation reaction, migration of an alkyl or aryl group takes place from the carbonyl carbon of the amide to the nitrogen atom. The amine so formed contains one carbon less than that present in the amide. |
