Sickle cell anaemia is :
Answer & explanation
Correct answer: option 1
The correct answer is Option (1) → An autosome linked recessive disease
Option (1) An autosome linked recessive disease — Correct. Sickle-cell anaemia is an autosome linked recessive trait. It is passed from parents to offspring when both partners are carriers (heterozygous HbAHbS).
Option (2) An autosome linked dominant disease — Incorrect. Sickle-cell anaemia is autosome linked but recessive: only HbSHbS homozygotes show the disease, while heterozygous carriers are unaffected. A dominant trait would show in the carriers too.
Option (3) Sex linked recessive disease — Incorrect. The gene is on an autosome (chromosome 11), not on a sex chromosome.
Option (4) Mineral deficiency disease — Incorrect. It is a genetic disease, not caused by lack of a mineral.
Note: A similar question was also asked in CUET (UG) 2023 on 30-05-2023 (Slot 1).
NCERT Extract:
Mendelian Disorders – “… Sickle-cell anaemia : This is an autosome linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for the gene (or heterozygous). The disease is controlled by a single pair of allele, HbA and HbS. Out of the three possible genotypes only homozygous individuals for HbS (HbSHbS) show the diseased phenotype.”