The person with karyotype 44+XXY is suffering from:

The correct answer is Option (2) → Klinefelter's Syndrome

Option (1) Down's Syndrome — Incorrect. Down's syndrome is trisomy of chromosome 21, an extra autosome. The sex chromosomes are normal.

Option (2) Klinefelter's Syndrome — Correct. 44 autosomes + XXY = 47 chromosomes. The person is male but sterile, with some feminine features.

Option (3) Turner's Syndrome — Incorrect. Turner's syndrome is the loss of one X chromosome (44 + X0, 45 chromosomes) in females.

Option (4) Edward's Syndrome — Incorrect. Edward's syndrome is trisomy of chromosome 18, an autosome. NCERT does not describe it; it does not involve the sex chromosomes.

NCERT Extract:
Chromosomal Disorders – “… Klinefelter’s Syndrome : This genetic disorder is also caused due to the presence of an additional copy of X-chromosome resulting into a karyotype of 47, XXY. Such an individual has overall masculine development, however, the feminine development (development of breast, i.e., Gynaecomastia) is also expressed (Figure 4.17 a).”

Figure 4.17 Diagrammatic representation of genetic disorders due to sex chromosome composition in humans : (a) Klinefelter Syndrome; (b) Turner’s Syndrome