The most appropriate synonym of the word despise is abhor.
- Despise means "to regard with extreme aversion or intense dislike."
- Approve means "to have a favorable opinion of; to think well of."
- Abhor means "to regard with extreme repugnance or hate."
- Admire means "to regard with respect or admiration."
- Adore means "to love or worship with great intensity."
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