Addison's disease is not characterised by

Modulated inflammatory reactions.

The correct answer is Option (4) → Modulated inflammatory reactions.

Addison's disease is primary adrenal insufficiency, leading to decreased secretion of glucocorticoids (cortisol) and mineralocorticoids (aldosterone). Common features include:

• Hypoglycemia  True (due to low cortisol)
• Weakness in the body  True (due to low cortisol and aldosterone)
• Increased susceptibility to stress  True (cortisol is essential for stress response)
• Modulated inflammatory reactions  False – cortisol deficiency actually increases inflammatory responses, rather than modulating them.