Match the LIST-I with LIST-II
| LIST-I | LIST-II |
|---|---|
| Scientists | Contributions |
| A. Alfred Hershey | I. Transforming principle |
| B. Franklin Stahl | II. DNA fingerprinting |
| C. Frederick Griffith | III. DNA as genetic material |
| D. Alec Jeffreys | IV. Replication of DNA |
Choose the correct answer from the options given below:
Answer & explanation
Correct answer: option 2
The correct answer is Option (2) → A-III, B-IV, C-I, D-II
(A) Alfred Hershey — this matches (III) DNA as genetic material. Hershey and Martha Chase grew bacteriophages with radioactive phosphorus (for DNA) and radioactive sulphur (for protein). Only the radioactive DNA entered the bacteria, which proved that DNA is the genetic material.
(B) Franklin Stahl — this matches (IV) Replication of DNA. Meselson and Stahl grew E. coli first in 15N and then in 14N. The DNA of the following generations proved that DNA replicates semi-conservatively.
(C) Frederick Griffith — this matches (I) Transforming principle. In his experiment on Streptococcus pneumoniae, the harmless R strain was changed into the killer S strain by something from heat-killed S bacteria. He called it the ‘transforming principle’.
(D) Alec Jeffreys — this matches (II) DNA fingerprinting. He first developed the technique, using a VNTR sequence as the probe.