Read the Passage carefully and answer the questions. Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges. The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency. This enzyme is crucial for the immune system to function. Recombinant DNA technology, Polymerase Chain Reaction (PCR) and Enzyme Linked Immuno-sorbent Assay (ELISA) are some of the techniques that serve the purpose of early diagnosis of diseases. Transgenic animals that produce useful biological products can be created by the introduction of the portion of DNA (or genes) which codes for a particular product such as human protein (a-1-antitrypsin) used to treat emphysema. Biopiracy is the term used to refer to the use of bio-resources by multinational companies and other organisations without proper authorisation from the countries and people concerned without compensatory payment. |
Transgenic animals that produce useful biological products can be created by the introduction of the portion of DNA which codes for a particular product such as human protein (α-1-antitrypsin) which is used to treat: |
Phenylketonuria Emphysema Cystic fibrosis Adenosine deaminase deficiency |
Emphysema |
The correct answer is Option (2) → Emphysema Medicines required to treat certain human diseases can contain biological products, but such products are often expensive to make. Transgenic animals that produce useful biological products can be created by the introduction of the portion of DNA (or genes) which codes for a particular product such as human protein (α-1-antitrypsin) used to treat emphysema. Similar attempts are being made for treatment of phenylketonuria (PKU) and cystic fibrosis. In 1997, the first transgenic cow, Rosie, produced human protein-enriched milk (2.4 grams per litre). The milk contained the human alpha-lactalbumin and was nutritionally a more balanced product for human babies than natural cow-milk. |