Which toxic substance is responsible for the chills and high fever recurring every three to four days in malarial fever ?

Sporozoite Haemozoin Colostrum None of these

Haemozoin

The parasites initially multiply within the liver cells and then attack the red blood cells (RBCs) resulting in their rupture. The rupture of RBCs is associated with release of a toxic substance, haemozoin, which is responsible for the chill and high fever recurring every three to four days.