The correct answer is Option (4) → Benign
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Malignant (Adjective) means very infectious; virulent, or more commonly in medicine, (of a disease) very harmful and likely to get worse, often leading to death (e.g., a cancerous tumor).
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Benign (Adjective) means gentle; kindly, or in medicine, (of a disease) not harmful in effect; not threatening to life (e.g., a non-cancerous tumor).
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Malaise (Noun): A general feeling of discomfort, illness, or unease whose exact cause is difficult to identify. (Unrelated)
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Toxic (Adjective): Poisonous. This is often a synonym for or closely related to malignant in its harmful meaning.
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Rare (Adjective): Not occurring very often. (Unrelated)
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