Which of the following diseases is caused by a severe protein deficiency?

Kwashiorkor

The correct answer is Option (4) - Kwashiorkor

A severe case of protein-energy deficiency is called kwashiorkor.

Edema, irritability, anorexia, ulcerating dermatoses, and an enlarged liver with fatty infiltrates are its defining features.

It differs from marasmus in that it consumes enough calories but not enough protein.