The most appropriate antonym of the word "vitiate" is affirm.
- Vitiate means to make something less effective or valuable by making it corrupt or impure.
- Affirm means to state or declare something positively or emphatically.
The other words in the list are not antonyms of "vitiate".
- Violate means to break or disregard a law, rule, or agreement.
- Annul means to make something legally invalid or ineffective.
- Cancel means to make something no longer valid or effective.
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