Select the most appropriate one-word substitution for the given group of words. 

Annoyance or distress at having failed or been humiliated.

Chagrin

The most appropriate one-word substitution for annoyance or distress at having failed or been humiliated is chagrin.

• Panacea is a cure-all.
• Creche is a place where young children are cared for while their parents are at work.
• Abattoir is a place where animals are slaughtered for food.

The word chagrin is derived from the French word chagrin, meaning "grief" or "annoyance". It is a feeling of annoyance or distress, especially at having failed or been humiliated.