Read the following passage carefully and answer the given questions. We use microbes and microbially derived products almost every day. Bacteria called lactic acid bacteria (LAB) grow in milk to convert it into curd. The dough, which is used to make bread, is fermented by yeast called Saccharomyces cerevisiae. Microbes are used to produce industrial products like lactic acid, acetic acid and alcohol, which are used in a variety of processes in the industry. However, certain bacteria, which grow anaerobically on cellulosic material, produce large amount of methane along with $CO_2$ and $H_2$. These bacteria are collectively called methanogens, and one such common bacterium is Methanobacterium. These bacteria are commonly found in the anaerobic sludge during sewage treatment. Microbes are also used for commercial and industrial production of certain chemicals like organic acids, alcohols and enzymes. Examples of acid producers are Aspergillus niger (a fungus) of citric acid. You are familiar with the commonly used antibiotic Penicillin. Do you know that Penicillin was the first antibiotic to be discovered, and it was a chance discovery? Statins produced by the yeast Monascus purpureus have been commercialised as blood-cholesterol lowering agents. It acts by competitively inhibiting the enzyme responsible for synthesis of cholesterol. |
The discovery of penicillin was a chance discovery by Alexander Fleming while working on: |
Staphylococci Penicillium notatum Lactobacillus Clostridium butylicum |
Staphylococci |
The correct answer is Option (1) → Staphylococci Antibiotics produced by microbes are regarded as one of the most significant discoveries of the twentieth century and have greatly contributed towards the welfare of the human society. Antibiotics are chemical substances, which are produced by some microbes and can kill or retard the growth of other (disease-causing) microbes. Alexander Fleming while working on Staphylococci bacteria, once observed a mould growing in one of his unwashed culture plates around which Staphylococci could not grow. He found out that it was due to a chemical produced by the mould and he named it Penicillin after the mould Penicillium notatum. However, its full potential as an effective antibiotic was established much later by Ernest Chain and Howard Florey. This antibiotic was extensively used to treat American soldiers wounded in World War II. Fleming, Chain and Florey were awarded the Nobel Prize in 1945, for this discovery. |