Select the most appropriate option to fill in the blank.

People have overcome poverty, drug addiction, abuse, divorce, mental illness, and virtually every ______ known to man.

Challenge

The most appropriate option to fill in the blank is challenge.

The word challenge means a difficult task or situation that tests someone's abilities. In this case, the sentence is saying that people have overcome poverty, drug addiction, abuse, divorce, mental illness, and virtually every challenge known to man. This means that people have faced and overcome many difficult obstacles in their lives.

The other options are not correct.

• Defiance means a deliberate act of disobedience or resistance. It cannot be used in this sentence because it does not describe a difficult task or situation.
• Dispute means a disagreement or argument. It cannot be used in this sentence because it does not describe a difficult task or situation.
• Objection means a feeling of disapproval or protest. It cannot be used in this sentence because it does not describe a difficult task or situation.