The most appropriate antonym of the word agitate is soothe.
- Agitate means "to cause (someone or something) to be restless or disturbed."
- Soothe means "to make (someone or something) feel calm or relaxed."
The other words do not have the same meaning as agitate, so they are not its antonyms.
- Blame means "to find (someone) responsible for something wrong or bad."
- Strike means "to hit (someone or something) forcefully."
- Distress means "to cause (someone) to feel great sadness, anxiety, or pain."
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