Amniocentesis is used in the prenatal diagnosis of:

The correct answer is Option (1) → Chromosomal abnormalities

Option (1) Chromosomal abnormalities — Correct. Amniocentesis is a foetal sex determination test based on the chromosomal pattern in the amniotic fluid around the developing embryo. It is used to detect chromosomal (genetic) abnormalities, though it is misused to find the sex of the foetus.

NCERT Extract:
Reproductive Health – Problems and Strategies – “… Statutory ban on amniocentesis for sex-determination to legally check increasing menace of female foeticides, massive child immunisation, etc., are some programmes that merit mention in this connection. In aminocentesis some of the amniotic fluid of the developing foetus is taken to analyse the fetal cells and dissolved substances. This procedure is used to test for the presence of certain genetic disorders such as, down syndrome, haemoplilia, sickle-cell anemia, etc., determine the survivability of the foetus.”