Gayatri is a 40 years old woman who has reported to be having constant sleep problems, tiredness and weight issues. She is unable to think clearly and suffers from excessive guilt and feelings of worthlessness. She is withdrawn, moody and often has thoughts of death. What is Gayatri suffering from?

Major depressive disorder

Based on the symptoms described, Gayatri appears to be suffering from Major Depressive Disorder (MDD).

Major depressive disorder is defined as a period of depressed mood and/or loss of interest or pleasure in most activities, together with other symptoms which may include change in body weight, constant sleep problems, tiredness, inability to think clearly, agitation, greatly slowed behaviour, and thoughts of death and suicide. Other symptoms include excessive guilt or feelings of worthlessness.