Match column 1 with column 2 :

A-iii, B-ii, C-i, D-iv

The correct answer is option (2) -A-iii, B-ii, C-i, D-iv

Sickle-cell anaemia : This is an autosome linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for the gene (or heterozygous). The disease is controlled by a single pair of allele, Hb^A and Hb^S. Sickle-cell anaemia is a qualitative problem of synthesising an incorrectly functioning globin.

Phenylketonuria is an inborn error of metabolism is inherited as an autosomal recessive trait. The affected individual lacks an enzyme that converts the amino acid phenylalanine into tyrosine.

Klinefelter’s Syndrome : This genetic disorder is also caused due to the presence of an additional copy of X- chromosome resulting into a karyotype of 47, XXY. Such an individual has overall masculine development, however, the feminine development (development of breast, i.e., Gynaecomastia) is also expressed. Such individuals are sterile.

Color Blindness: It is a sex-linked recessive disorder due to defect in either red or green cone of eye resulting in failure to discriminate between red and green colour. This defect is due to mutation in certain genes present in the X chromosome. It occurs in about 8 per cent of males and only about 0.4 per cent of females. This is because the genes that lead to red-green colour blindness are on the X chromosome.