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The sex linked recessive disease, which shows its transmission from unaffected carrier female to some of the male progeny has been widely studied. In this disease, a single protein that is a part of the cascade of proteins involved in the clotting of blood is affected. Due to this in an affected individual a simple cut will result in non-stop bleeding. The heterozygous female (carrier) for the disease may transmit it to sons. The possibility of a female becoming a sufferer of disease is extremely rare because mother of such a female has to be at least carrier and the father should be sufferer. The family pedigree of Queen Victoria shows a number of suffering descendents as she was a carrier of the disease.