Select the most appropriate option to fill in the blank and complete the collocation.

Always be in _____ with your near and dear ones as life is uncertain and fragile.

touch

The most appropriate option to fill in the blank and complete the collocation is touch.

The collocation "be in touch" means to stay in communication with someone. It is the most appropriate option in this context because it conveys the idea of keeping up with your loved ones and staying connected to them.

The other options do not make sense in the context of the sentence.

• "Relation" means a connection between two or more people or things. It does not make sense to say that you should always be in relation with your near and dear ones.
• "Communication" is a broader term than "touch" and it does not convey the specific idea of staying in contact with someone.
• "Connection" is similar to "relation" and it does not make sense to say that you should always be in connection with your near and dear ones.