Arrange the following events of malarial infection in human beings sequencially:

(A) Transmission of gametocyte to female mosquito
(B) Gametocyte development in RBC
(C) Multiplication of parasite in RBC and rupturing of RBC
(D) Biting by female Anopheles mosquito and transmission of sporozoites
(E) Multiplication of parasite in liver cell

Choose the correct answer from the options given below:

(D), (E), (C), (B), (A)

The correct answer is Option (1) → (D), (E), (C), (B), (A)

(D) Biting by female Anopheles mosquito and transmission of sporozoites

(E) Multiplication of parasite in liver cell

(C) Multiplication of parasite in RBC and rupturing of RBC

(B) Gametocyte development in RBC

(A) Transmission of gametocyte to female mosquito

Explanation of the Sequence:

(D) Biting by female Anopheles mosquito and transmission of sporozoites:

• The infection begins when a female Anopheles mosquito bites a human and injects sporozoites (the infective form of the malaria parasite) into the bloodstream.

(E) Multiplication of parasite in liver cell:

• The sporozoites travel to the liver, where they infect liver cells and multiply. This stage is called the exo-erythrocytic or liver stage.

(C) Multiplication of parasite in RBC and rupturing of RBC:

• After leaving the liver, the parasites enter the red blood cells (RBCs), where they multiply further, eventually causing the RBCs to rupture and release more parasites into the bloodstream.

(B) Gametocyte development in RBC:

• Some of the parasites in the RBCs develop into sexual forms called gametocytes.

(A) Transmission of gametocyte to female mosquito:

• When another female Anopheles mosquito bites the infected person, it takes up these gametocytes, which then develop into mature gametes in the mosquito's gut, continuing the cycle.

   

   

  

   

•                                   Stages in the life cycle of Plasmodium