The production of the toxic substance haemozoin is associated with:

The correct answer is Option (2) → RBCs

Haemozoin is a toxic substance made in malaria. The malarial parasite Plasmodium multiplies inside the red blood cells and bursts them. Each burst releases haemozoin, which causes the chill and high fever that return every three to four days.

(1) Lymphocytes — Incorrect. These are white blood cells (B and T cells) that give immunity. They do not make haemozoin.

(2) RBCs — Correct. The release of haemozoin is linked to the rupture of RBCs.

(3) Liver cells — Incorrect. The parasite first multiplies in the liver cells, but haemozoin is released only when the RBCs rupture.

(4) Leukocytes — Incorrect. These are the white blood cells that fight infection. They are not the cells that burst in malaria.

NCERT Extract:
Common Diseases in Humans – …