According to Buddha what is the cause of suffering and misery in human lives?

Desires

The correct answer is Option 1- Desires

According to Buddha, the cause of suffering and misery in human lives is desires.

Buddha taught that all suffering is caused by our attachment to things, people, and ideas. When we don't get what we want, we suffer. When we lose what we have, we suffer. And even when we have what we want, we still suffer because we are always afraid of losing it.

The way to end suffering is to let go of our desires. This does not mean that we should not have any goals or aspirations. It simply means that we should not be attached to the outcome of our actions. We should act for the sake of acting, without any expectation of reward or punishment.