The most appropriate antonym of the word despair is hope.
- Despair means "a feeling of complete hopelessness and discouragement."
- Hope means "a feeling of expectation and desire for a particular thing to happen."
The other words have different meanings to despair, so they are not good antonyms.
- Vile means "extremely unpleasant or disgusting."
- Annoy means "to cause someone to feel slightly irritated or frustrated."
- Definite means "clearly stated or decided; leaving no doubt."
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