The correct answer is option 4. Oppose.
The most appropriate antonym of the word uphold is oppose.
- Uphold means "to support or defend (something) against opposition or criticism."
- Support means "to give assistance to or encouragement to (someone or something)."
- Maintain means "to keep (something) in existence or in a particular state."
- Endorse means "to give one's approval or support to (something)."
- Oppose means "to be against (something) and try to prevent it from happening."
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