How can you trace the inheritance pattern of Mendelian disorder in a family?
Answer & explanation
Correct answer: option 2
The correct answer is Option (2) → Using Pedigree Analysis
To trace the inheritance pattern of a Mendelian disorder (e.g., cystic fibrosis, sickle-cell anemia, or Huntington’s disease) in a family, the most effective method is:
Pedigree Analysis:
- A family tree diagram that tracks the presence/absence of a trait across generations.
- Helps determine if the disorder is:
- Autosomal dominant/recessive
- X-linked dominant/recessive
- Example: If a disorder skips generations, it suggests autosomal recessive inheritance.
Other Options:
- DNA fingerprinting: Used for identity verification or paternity testing, not inheritance patterns.
- Chromosomal mapping: Identifies gene locations but doesn’t show familial transmission.
- None of these: Incorrect, as pedigree analysis is the standard method.
Key Point:
Pedigree analysis visually reveals Mendelian patterns (dominant/recessive, sex-linked).
Answer: Using Pedigree Analysis