How can you trace the inheritance pattern of Mendelian disorder in a family?

Using Pedigree Analysis

The correct answer is Option (2) →  Using Pedigree Analysis

To trace the inheritance pattern of a Mendelian disorder (e.g., cystic fibrosis, sickle-cell anemia, or Huntington’s disease) in a family, the most effective method is:

Pedigree Analysis:

• A family tree diagram that tracks the presence/absence of a trait across generations.
• Helps determine if the disorder is:
• Autosomal dominant/recessive
• X-linked dominant/recessive
• Example: If a disorder skips generations, it suggests autosomal recessive inheritance.

Other Options:

• DNA fingerprinting: Used for identity verification or paternity testing, not inheritance patterns.
• Chromosomal mapping: Identifies gene locations but doesn’t show familial transmission.
• None of these: Incorrect, as pedigree analysis is the standard method.

Key Point:

Pedigree analysis visually reveals Mendelian patterns (dominant/recessive, sex-linked).

Answer: Using Pedigree Analysis