The most appropriate synonym of the given word breakthrough is discovery.
- Breakthrough means "a significant advance or discovery."
- Discovery means "the act of finding something that was previously unknown or hidden."
- Disaster means "a sudden, calamitous event; a catastrophe."
- Coincidence means "the chance occurrence of events that seem to have a causal connection, especially when these events are considered improbable."
- Accident means "an unfortunate event that happens unexpectedly and unintentionally, typically resulting in damage or injury."
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