Practicing Success
If a haemophilic man marries a woman which is carrier (heterozygous) for haemophilia, what would be the possibility that their son would be haemophilic ? |
75% 50% 0% 100% |
50% |
The correct answer is Option (2) - 50% Haemophilic Man (Father): The father, being haemophilic, has a genotype of XhY, where XhY represents the gene for haemophilia. Since males have one X chromosome and one Y chromosome, he can only pass the Y chromosome to his sons. Carrier Woman (Mother): The mother is a carrier of haemophilia, meaning she carries one normal X chromosome and one X chromosome with the haemophilia gene (Xh). So her genotype is XXh. Sons: The sons inherit one X chromosome from their mother (either X or Xh) and the Y chromosome from their father. So, they can either be XhY (haemophilic) or XY (normal). Since the XhY genotype leads to haemophilia, there's a 50% chance that their sons will be haemophilic. Daughters: The daughters inherit one X chromosome from each parent. They can be XXh (carrier), or XhXh (haemophilic). In this case, they have a 50% chance of being carriers XXh and a 50% chance of being haemophilic XhXh . So, the overall probability that their son would be haemophilic is 50%. |