A mutation is a change in the DNA of an organism. The change may or may not result a change to the physical characteristics (or phenotype) of the organism. Mutations that occur in a gamete (sperm or eggs) can be passed to the next generation, whereas mutations that occur in body (or 'somatic') cells may be harmless or may result in a disease such as cancer. Mutations can result in DNA being copied incorrectly. Mutagens can also cause mutations.

A point mutation is a change in one base in the genetic code. The change of one base to a different base (often caused by the DNA being copied incorrectly)-this is called a substitution mutation.

Autosomal mutations may result in:

Disease in an individual

The correct answer is Option (1) → Disease in an individual

Autosomal mutations refer to changes in the genes on autosomes (non-sex chromosomes). These mutations can alter gene function and lead to genetic disorders or diseases, depending on whether the mutation disrupts critical functions or introduces harmful changes.

Predictable change in an individual is not entirely accurate, as mutations are often random and unpredictable in their effects.

Always beneficial change for evolution is incorrect because mutations can be neutral, harmful, or occasionally beneficial; they are not necessarily advantageous.

Affecting the cell division at metaphase is not a direct outcome of autosomal mutations, though some mutations can indirectly impact cell cycle processes.