Select the most appropriate option to fill in the blank.

The little puppy was _______ by a speeding car.

run over

The correct option to fill in the blank is run over.

The sentence is about the unfortunate accident that happened to the puppy. The puppy was run over by a speeding car, which means that the car's tires passed over the puppy's body. This caused the puppy to suffer serious injuries or death.

The other options are not as appropriate.

• Run away does not make sense in the context of the sentence. It could be interpreted as the puppy was trying to escape from the car, but this is not what the sentence is trying to say.
• Run at does not make sense in the context of the sentence. It could be interpreted as the puppy was charging at the car, but this is not what the sentence is trying to say.
• Run into does not make sense in the context of the sentence. It could be interpreted as the puppy bumped into the car, but this is not what the sentence is trying to say.