The most appropriate antonym of the word ‘Sane’ in the given sentence is crazy.

• Sane means of sound mind; rational.
• Crazy means mentally deranged; mad.

Therefore, the antonym of sane must mean the opposite of sound mind or rational. Of the above choices, only crazy has the opposite meaning of sane.

The other choices are not antonyms of sane.

• End means the final point or limit of something. This is not the opposite of sane, as sane does not refer to the end of something.
• Beautiful means very attractive or pleasing. This is not the opposite of sane, as sane does not refer to attractiveness or beauty.
• Delicious means extremely pleasant to taste. This is not the opposite of sane, as sane does not refer to taste.

Therefore, the correct answer is crazy.