The probability of having a haemophilia carrier daughter by a haemophilia carrier mother and a normal father is:
Answer & explanation
Correct answer: option 3
The correct answer is Option (3) → 25%
Carrier mother XhX × normal father XY gives four equally likely children: XhX (carrier daughter), XX (normal daughter), XhY (affected son) and XY (normal son). One of the four is a carrier daughter: 25 per cent.
Option (2) 50% — Incorrect. 50 per cent is the share among the daughters only.
Option (3) 25% — Correct. The mother is a carrier (XhX) and the father is normal (XY). Their children are XX, XY, XhX and XhY in equal numbers, so the chance of a carrier daughter (XhX) is 1 in 4 = 25 per cent.
NCERT Extract:
Mendelian Disorders – “… Haemophilia : This sex linked recessive disease, which shows its transmission from unaffected carrier female to some of the male progeny has been widely studied. In this disease, a single protein that is a part of the cascade of proteins involved in the clotting of blood is affected. Due to this, in an affected individual a simple cut will result in non-stop bleeding. The heterozygous female (carrier) for haemophilia may transmit the disease to sons.”