Select the most appropriate word to fill in the blank.

______ the train was late by six hours, it made up three hours before reaching its destination.

Although

The correct word to fill in the blank is Although.

• In spite of means "even though" or "despite." It is used to introduce a statement that contradicts the main statement in the sentence. In this case, it would mean that the train was late by six hours despite the fact that it made up three hours before reaching its destination. This is not the correct meaning of the sentence.
• Because means "for the reason that." It is used to introduce a statement that explains the reason for something else in the sentence. In this case, it would mean that the train was late by six hours because it made up three hours before reaching its destination. This is not the correct meaning of the sentence.
• In case means "in preparation for." It is used to introduce a statement that describes something that might happen. In this case, it would mean that the train was late by six hours in case it made up three hours before reaching its destination. This is not the correct meaning of the sentence.