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Home Questions J5W33HEYA6
Target Exam

CUET

Subject

Biology

Chapter

Principles of Inheritance and Variation

Question:

Which among the following statement is incorrect about haemophilia ?

Options:

This is a sex linked dominant disease .

Transmission from unaffected carrier female to some of the male progeny .

A single protein that is a part of the cascade of proteins involved in the clotting of blood is affected .

The possibility of a female becoming a haemophilic is extremely rare .

Correct Answer:

This is a sex linked dominant disease .

Explanation:

The incorrect statement among the options provided about hemophilia is:

"This is a sex-linked dominant disease."

Hemophilia is not a sex-linked dominant disease; it is a sex-linked recessive disorder. Hemophilia is caused by a mutation in genes located on the X chromosome, and it primarily affects males. The gene for hemophilia is recessive and located on the X chromosome. Because males have only one X chromosome, if they inherit the affected X chromosome from their mother, they will display the hemophilia trait. Females need to inherit two affected X chromosomes (one from each parent) to express the disorder since they have two X chromosomes. Carrier females (heterozygous) are usually asymptomatic but can pass on the affected gene to their offspring.

Therefore, the incorrect statement is that hemophilia is a sex-linked dominant disease; in reality, it is a sex-linked recessive disorder.

 In this disease, a single protein that is a part of the cascade of proteins involved in the clotting of blood is affected. Due to this, in an affected individual a simple cut will result in non-stop bleeding. The heterozygous female (carrier) for haemophilia may transmit the disease to sons. The possibility of a female becoming a haemophilic is extremely rare .

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