Match List-I with List-II
| LIST-I | LIST-II |
|---|---|
| Genetic disorders | Features |
| (A) Thalassemia | (I) Absence of one X chromosome |
| (B) Haemophilia | (II) Autosomal linked recessive disease |
| (C) Turner’s syndrome | (III) Trisomy of 21 |
| (D) Down’s syndrome | (IV) Sex linked recessive disease |
Choose the correct answer from the options given below:
Answer & explanation
Correct answer: option 1
The correct answer is Option (1) → (A) - (II), (B) - (IV), (C) - (I), (D) - (III)
(A) Thalassemia — this matches (II) Autosomal linked recessive disease. The gene lies on an autosome, and the disease shows only when a child gets the faulty gene from both carrier parents. A mutation or deletion lowers the making of one of the globin chains of haemoglobin, which causes anaemia.
(B) Haemophilia — this matches (IV) Sex linked recessive disease. The gene is on the X chromosome. A protein needed for blood clotting is affected, so even a small cut keeps bleeding. A carrier mother passes it to her sons.
(C) Turner’s syndrome — this matches (I) Absence of one X chromosome. The person has 45 chromosomes with the karyotype 45 + XO. Such females are sterile because their ovaries are rudimentary.
(D) Down’s syndrome — this matches (III) Trisomy of 21. There is an extra copy of chromosome 21. The person is short, with a small round head, a furrowed tongue and a partly open mouth, and has slow physical and mental development.
Note: A similar question was also asked in CUET (UG) 2025 on 29-05-2025 (Slot 1), and in CUET (UG) 2022 on 20-08-2022 (Slot 1).