Practicing Success
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| What is the site of production of ADA in the body ? |
Lymphocytes
Erythrocytes
Blood plasma
None of these |
| Lymphocytes |
| ADA is crucial for the immune system to function. The disorder is caused due to the deletion of the gene for adenosine deaminase. As a first step towards gene therapy, lymphocytes from the blood of the patient are grown in a culture outside the body. A functional ADA cDNA (using a retroviral vector) is then introduced into these lymphocytes, which are subsequently returned to the patient. However, as these cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes. |
