Fill in the blank with the correct preposition.
I do not agree__________you regarding this issue.

with

The correct preposition to fill in the blank is with. The preposition with is used to indicate agreement or disagreement. In this case, I do not agree with you regarding this issue, which means that I do not share your opinion on this issue.

The other options are incorrect.

• To is used to indicate direction or purpose.
• In is used to indicate location or position.
• At is used to indicate a specific point or place.